Clinico-pathological profile of patients with suspected cervical carcinoma

Background: Cervical cancer in India accounts for 1/4 th cancer burden of world. Morbidity and mortality due to cervical cancer declined dramatically in developed countries after introduction of cytology based screening programs and quality treatment. ObjectiveTo find out proportion of and pattern of cellular atypia and dysplasia, to evaluate ASCUS/ LSIL cases with colposcopy, HPV testing and histological examination. Methodology: A descriptive cross sectional study was conducted for one year at Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences (RMSPVIMS) involving 21-45 years married women attending Gynae & Obstetrics OPD with suggestive symptoms of cervical cancer. Eligible women were subjected to Pap smear followed by colposcopy, HPV DNA testing and histological examination if found to be Pap positive. Results: The most common (59.6%) presenting complaint was excessive white discharge. Pap smear screening revealed nearly 77% and 23% of participants had ASCUS and LSIL. Only 3.8% and 7.7% participants were positive for colposcopic and HPV testing. Histopathology report revealed 57.7%, 13.5% and 13.5% women had chronic cervicitis, adenomyosis and chronic cervicitis with adenomyosis, respectively. Evidence of early cervical carcinoma was seen in 15.4% specimens of which 7.7% were CIN I whereas CIN II and ‘early invasive carcinoma’ were 3.8% each. Both the patients with positive colposcopic finding had CIN II. Out of 7.7% women positive for HPV, 3.8% had CIN I and 3.8% had early invasive Ca. ConclusionConsiderable proportion of young women revealed to have reversible precancerous lesions indicating the need of screening by a suitable effective screening test at early age.